Importance of this development is dictated by appearance of panresistant superbacteria during recent years, which are resistant to all used antibiotics, that is why NLS-method and computer express-evaluation of activity and resistance of a large number of pathogenic microorganisms against all existing antibacterial (antiparasitic) preparations simultaneously, may become the only possible alternative to a modern medicine.
Appearance of an increasing number of new antibiotics and progressive multiplication of strains with acquired resistance forces urgent tightening of regulations on accuracy and quickness of evaluation methods and beginning of development of conceptually new modern computer methods for evaluation of microorganisms’ resistance.
Computer NLS-analysis method for evaluation of activity and resistance of microorganisms against antibacterial preparations.
The most fundamental changes in a methodology of antibiotic-resistance evaluation by computer NLS-analysis method are related to creation of:
1. a concept of interpretative consideration of antibiotic-sensitivity evaluation results, based on a non-linear modeling of a studied microorganism with following correction of data, acquired at spectral testing, and issuing of a clinically oriented recommendations on therapy;
2. a concept of virtual etalons of group preparations, that allows to shorted significantly time and volume of studies in search for reliable results;
3. a mathematical model of a verification system of antibiotic-sensitivity evaluation accuracy, that allows to greatly decrease a possibility of erroneous results;
4. a spectral-wave method of microorganisms’ activity and antibiotic-sensitivity evaluation, that allows to evaluate a level of an external entropy in molecules of albuminous compounds of a microorganism’s separate tissues, and in bases of ribonucleic and desoxynucleic acids under the influence of antibacterial preparations.
Nowadays, without consideration of abovementioned aspects, it is impossible to get well-timed and reliable results of microorganisms’ activity and antibiotic-sensitivity evaluation, and therefore to apply modern antibacterial (antiparasitic) remedies properly.
In addition, this technology regards a human organism and its bacterial (parasitic) agents, as a unitary system of biotic relations and identifies any functional changes in a human organism, caused by microorganisms, as a predisposition for development of not only infectious, but psychosomatic illnesses as well. Basing on this, the technology makes possible to determine a study program clearly, without unnecessary consultations, thus shortening time of an examination, which is important for correct and well-timed diagnosing and corresponding treatment.
Major changes in “Intruder” software: 1. System of pseudo-3D visualization, more than 100 of new organ models. 2. New version of a report (summary). 3. Automatic creation of a report (summary) with three levels of detailing. 4. Microorganisms database is extended (about 150 new etalons and images), separate etalons groups – “Viruses”, “Helminthes” and “Fungi” added. 5. Automatic search for bacteria, viruses, helminthes. 6. New etalons groups added: “Antibacterial preparations”, “Antiviral preparations”, “Antiparasitic preparations” and “Antifungal preparations”. 7. Feature of quick selection of standard crosscuts added. 8. Classification of a process stages in entropic analysis. 9. Graphic representation of etalons types by criteria: anabolic/catabolic and dry/wet. 10. Improved mathematical model of hardware data processing. 11. Improved algorithms of affected areas location with consideration of a process type (anabolic/catabolic). 12. New system of tissues proliferation evaluation in young patients.
Separate versions of this software, specialized for markets of Japan and China, with support of corresponding languages and national etalons databases, are also created.